Lisa can be used to refer to:
- LISA: THE FIRST, the 2012 exploration game originally released as just LISA.
- Lisa Armstrong, protagonist of LISA: THE FIRST and younger sister of Brad Armstrong.
- LISA: THE PAINFUL, the 2014 post-apocalyptic sidescrolling turn-based RPG.
- LISA: THE JOYFUL, the 2015 the direct sequel and DLC to LISA: THE PAINFUL.